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What'sNEW Archives, July-October 200430 Oct 2004
Horizontal transfer isn't something that occurred once or twice in the earliest history of life; it is a continuing and persistent means of creating biological novelty.
Andrew Knoll, Life on a Young Planet: The First Three Billion Years of Evolution on Earth, ISBN: 0-691-12029-3, Princeton University Press, 2003. p 29.
Pack-MULE transposable elements mediate gene evolution in plants. Geneticists from the University of Georgia and Washington University think so after examining Mutator–Like transposable Elements (MULEs) that are found in many eukaryotic genomes. In well-studied plants they are known to carry fragments of cellular genes. The researchers named these ones "Pack-MULEs". Their report in Nature states, "Functional analysis of amino acid sequences and proteomic data indicate that some captured gene fragments might be functional. Comparison of the cellular genes and Pack-MULE counterparts indicates that fragments of genomic DNA have been captured, rearranged and amplified over millions of years. Given the abundance of Pack-MULEs in rice and the widespread occurrence of MULEs in all characterized plant genomes, gene fragment acquisition by Pack-MULEs might represent an important new mechanism for the evolution of genes in higher plants." Later they report, "...Sequence acquisition must have occurred over a long time frame, perhaps millions of years, and might still be occurring." A sample indicates that 5% of the captured sequences are transcribed. The article concludes, "...About one-fifth of the identified Pack-MULEs contain fragments acquired from multiple genomic loci, thus demonstrating their potential to create novel genes through the duplication, rearrangement and fusion of diverse genomic sequences."
Ning Jiang, Zhirong Bao, Xiaoyu Zhang, Sean R. Eddy and Susan R. Wessler, "Pack-MULE transposable elements mediate gene evolution in plants" [abstract], p 569-573 v 431, Nature, 30 Sep 2004. In addition to genes from engulfed algae, diatoms also contain a mix of plant and animal DNA, for which horizontal transfer, by various means, provides the most economical account, we think. Evidence that any diatom gene was composed by standard duplcation and divergence is not mentioned. If we ask how species obtain new genetic programs, this research supports our hypothesis that are acquired from elsewhere, and not the theory that they are composed de novo.
E. Virginia Armbrust et al., "The Genome of the Diatom Thalassiosira Pseudonana: Ecology, Evolution, and Metabolism" [abstract], p 79-86 v 306, Science, 1 Oct 2004. Larger than Mercury or Pluto, Titan has an appreciable atmosphere — that's unique among moons in the solar system. Furthermore, the air's composition (mostly nitrogen) and surface pressure (1.6 Earth atmospheres) are comparable to Earth's. But at 95° K, the air on the surface is much colder.
Cassini-Huygens Mission to Saturn, NASA.
The Crusade Against Evolution, by Evan Ratliff, and "Biocosm" [on the same page] by George Gilder, Wired Magazine, Oct 2004. On this website we suggest that organisms acquire new genetic programs by gene transfer. This genetic study offers additional evidence that gene transfer, even among eukaryotes, is a robust process. The mainstream darwinian theory holds that new genetic programs are gradually composed under the pressure of natural selection. We have seen little evidence for that process. (We welcome any submissions or pointers thereto.)
Patrick J. Keeling and Yuji Inagaki, "A class of eukaryotic GTPase with a punctate distribution suggesting multiple functional replacements of translation elongation factor 1α" [abstract], 10.1073/pnas.0404505101, Proc. Natl. Acad. Sci. USA, online 18 Oct 2004.
Retroelements such as retrotransposons were once thought to be examples of "selfish genes," but this gene is clearly beneficial to the viral species carrying it. Interestingly, genes with similar diversity-generating casettes are already seen in various bacteria.
Sergei Doulatov, Asher Hodes, et al., "Tropism switching in Bordetella bacteriophage defines a family of diversity-generating retroelements" [abstract], p 476-481 v 431, Nature, 23 Sep 2004.
First Announcement, 36th Lunar and Planetary Science Conference, 14-18 March 2005. Jennifer Blank of Lawrence Livermore National Lab described experiments in which extreme impacts turned unjoined amino acids into larger peptides. (This is like explaining literature by explaining typesetting.) Later, Knoll admitted, "But the leap is staggeringly complex.... It's hard to get your head around." Right. Finally, the show emphasized the importance of cyanobacteria in creating the oxygenated atmosphere, which, we agree, is an important phase in the history of life on Earth. The final two episodes, "Where are the Aliens?" and "Back to the Beginning," will air tomorrow. Expect entertainment more than enlightenment.
Origins, four one-hour episodes on PBS, 8-10 PM, 28 & 29 September 2004. 26 Sep 2004
An article promoting Intelligent Design has been published in a peer-reviewed scientific journal. "The origin of biological information and the higher taxonomic categories," by Stephen C. Meyer, Director of Discovery Institute's Center for Science and Culture, appeared on 4 August 2004, in the Proceedings of the Biological Society of Washington, published at the National Museum of Natural History at the Smithsonian Institution in Washington D.C. Creationists feel vindicated by this publishing coup, and darwinists are outraged. (Tightly gridlocked as ever, both sides agree on one thing: there is no third alternative.)
We agree that Meyer's critique is not new, but we think the problem is still unsolved. In fact, we believe that the unsolved problem for darwinism extends well beyond the Cambrian explosion. Not only then, but throughout the history of life on Earth, new genetic programs have produced evolutionary advances. The standard theory holds that these new programs were composed within Earth's closed biosphere by unguided darwinian processes, but this composition process lacks confirmation. Neither closed-system experiments, nor historical reconstructions from genomic sequences convincingly demonstrate the composition of new programs. (We recognize the adequacy of biological evidence for adaptation, speciation, variation, optimization, etc., which processes are also easily demonstrated in computer models.) In a genetically open system new genetic programs could come from elsewhere. They could be installed by viruses and other familiar processes of lateral gene transfer, as cosmic ancestry requires and as many examples already illustrate. After installation, beneficial new programs could be favored (and optimized) by standard darwnian natural selection. In earlier essays we have challenged darwinism to demonstrate the composition of new genetic programs in closed-system experiments in biology or in computer models. If a convincing demonstration ever succeeds, we will retire. Until then, we think scientific alternatives like cosmic ancestry deserve consideration. [Thanks, Jerry Chancellor.]
Stephen C. Meyer, "The origin of biological information and the higher taxonomic categories," p 213-239 v 117 n 2, Proceedings of the Biological Society of Washington, Aug 2004 [posted by Discovery Institute]. 24 Sep 2004
Water vapor and methane concentrations are correlated in Mars' lower atmosphere. That they are concentrated in three regions at all implies that their release in those places is ongoing. And the correlation strengthens the possibility that the methane is biologically produced. The report comes from ESA's analysis of data from the Planetary Fourier Spectrometer aboard Mars Express. It was presented by Dr. Vittorio Formisano at the International Mars Conferrence in Ischia Italy, 19-23 September 2004. [Thanks, Larry Klaes, Jerry Chancellor, Justin Willingham and Marsbugs.]
Water and methane maps overlap on Mars: a new clue?, European Space Agency, 20 Sep 2004. 14 Sep 2004
Halobacteria can repair badly damaged DNA. "We have completely fragmented their DNA. ...And they can reassemble their entire chromosome and put it back into working order within several hours," says Adrienne Kish, a member of the research group studying Halobacteria at the University of Maryland. These Archaea can also survive extreme dryness, a hard vacuum, and of course, high salt concentrations. We are not the only ones to notice that Halobacteria could use these capabilities to survive in space. [Thanks, Chandra Wickramasinghe and Marsbugs.]Secrets of a Salty Survivor, Science@NASA, 10 Sep 2004. Bacteria... is a related CA webpage. Viruses... is a related CA webpage about gene transfer, in which DNA repair mechanisms may be essentlal participants. [Next-What'sNEW about HGT-Prev] 9 Sep 2004
The ring of life! Two molecular biologists in California have compared a dozen whole genomes from yeasts and prokaryotes to conclude, "The eukaryotic genome resulted from a fusion of two diverse prokaryotic genomes, and therefore ...the tree of life is actually a ring of life."
Using a new algorithm called "conditioned reconstruction," Maria Rivera and James Lake affirm the observation that "the informational genes of eukaryotes are primarily derived from Archaea and the operational genes are primarily derived from Bacteria." In passing they comment, "A substantial and continuous influx of mitochondrial DNA to the eukaryotic nucleus has been documented." Moreover, "The extensive horizontal transfer observed among prokaryotes can obscure the identities of those prokaryotes that may have contributed genes to eukaryotes." Tracking genes that retain their identities for billions of years, they mention no examples of genes that have acquired new functions by duplication and divergence. Instead, "The results derived in this paper argue against autogenous theories... in which eukaryotes are proposed to have evolved clonally from a single, possibly very ancient, prokaryote." Their conclusion strengthens our hunch that eukaryotes (not just prokaryotes) must acquire new genes, by whatever method, from beyond their own genomes.
Maria C. Rivera and James A. Lake, "The ring of life provides evidence for a genome fusion origin of eukaryotes" [abstract], p 152-155 v 431, Nature, 9 Sep 2004. 1 Sep 2004
Gene transfer among eukaryotes — Two independent studies show that there have been horizontal gene transfers between parasites and their vertebrate or plant hosts. "The huge significance of horizontal gene transfer for the evolution of prokaryotes has been known for a long time, as has the large contribution that intracellular endosymbiont ancestors of mitochondria and chloroplasts have made to eukaryotic genomes.... Studies such as these show that ongoing horizontal gene transfer from a range of parasites and endosymbionts might be more important for eukaryotic evolution than we previously realized — just how important remains to be seen."Nick Campbell, "Genome Evolution: Give and take" [article], p 638-639 v 5, Nature Reviews Genetics, Sep 2004. Charles C. Davis and Kenneth J. Wurdack, "Host-to-Parasite Gene Transfer in Flowering Plants: Phylogenetic Evidence from Malpighiales" [abstract], p 66-678 v 304, Science, 30 Jul 2004. N. Nitz et al., "Heritable integration of kDNA minicircle sequences from Trypanosoma cruzi into the avian genome: insights into human Chagas disease" [RETRACTED!], p 175-186 v 118, Cell, 23 Jul 2004. Constance Holden, "Withdrawn Parasite Paper Stirs Criticism of Cell" [link], p 34 v 310, Science, 7 Oct 2005. Viruses... is a related CA webpage with lots about gene transfer. [Next-What'sNEW about HGT-Prev] 31 Aug 2004 Changing spots on Mars that grow in spring on the dunes near Mars' North Pole are the subject of the "Astronomy Picture of the Day". In spite of the way they look, NASA does not believe they are biological.The Dotted Dunes of Mars, Astronomy Picture of the Day, 31 Aug 2004. Dark spots which spread every Martian spring... is CA's first notice of the phenomenon, 7 Sep 2001. More about the changing dark spots on Mars gives another example of the phenomenon, 31 Jan 2002. More changing spots on Mars shows another example of the phenomenon, 5 Nov 2003. Life on Mars! is a related CA webpage. 2 Aug 2004 Microfossils in a meteorite — at The International Symposium on Optical Science and Technology in Denver, Colorado, Richard B. Hoover of NASA/NSSTC in Huntsville, Alabama announced the possible detection of a fossilized cyanobacterial mat in the interior of the Orgueil carbonaceous meteorite.
Microfossils in meteorites have been reported before now (see related webpages linked below), but critics say that they may have been left by earthly contaminants. Yet the newly seen microfossils can hardly be contaminants because they are not isolated single cells, but whole ecologies whose earthly examples grow only under conditions that the meteorite fragment never experienced after landing here. Conference attendees agreed that the new evidence, soon to be published in the Conference Proceedings, is momentous. Meanwhile, Hoover's group is gathering additional images and data for submission to a peer-reviewed scientific journal. For Hoover's discussion, a larger photo, and corroborating photos from Russia, see our new webpage linked (first) below.
Evidence for Indigenous Microfossils in a Carbonaceous Meteorite is the new CA webpage with the full report and several images. 27 July 2004
More about photosynthesis by gene transfer. In 2002, geneticists Raymond, Zhaxybayeva et al. used whole genome comparisons to conclude that photosynthesis in five groups of prokaryotes was acquired by gene transfer. In 2003, biologists at the University of Warwick found photosynthesis genes in a virus, S-PM2. Now, a team of biologists from Boston and San Diego "report the presence of genes central to oxygenic photosynthesis in the genomes of three phages from two [other] viral families...." The abstract of their writeup mildly concludes, "These gene transfers are likely to play a role in the fitness landscape of hosts and phages in the surface oceans." We note that evidence supporting gene transfer as the source for new genetic programs continues to accumulate. Meanwhile, evidence supporting a darwinian mechanism as the source for new genetic programs is lacking.
Debbie Lindell et al., "Transfer of photosynthesis genes to and from Prochlorococcus viruses" [abstract], p 11013-11018 v 101, Proc. Natl. Acad. Sci. USA, 27 July 2004.
25 July 2004
100 years old, Ernst Mayr reviews the development evolutionary thought in Science. We only wish that his interest in diversity and speciation included an equally penetrating curiosity about the sources of genetic programs for new features. Perhaps another of his stature will come along to explore that issue. [Thanks, Stan Franklin.]Ernst Mayr, "80 Years of Watching the Evolutionary Scenery" [summary], p 46-47 v 305, Science, 2 July 2004. Neo-Darwinism... is a related CA webpage. 08 July 2004
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