Subject: Transposons in germline
Date: Fri, 7 Sep 2001 13:19:43 -0800
From: Damon Lisch
Dear Brig
I happened to run across an article you wrote in January for the OSETI III Conference. Since you made reference to a manuscript by Margaret Kidwell and me, I though I should clear up some confusion. You wrote:
..."Horizontal gene transfer also works in higher eukaryotes, where we used to hear that the germ line was protected from invasion. The very opposite may be the case. In February 2000, Kidwell and Lisch 6 announced that some transposable elements preferentially target the germline cells and avoid somatic cells when they invade".
We were refering to the propensity of some transposons to downregulate themselves in somatic tissue where they would cause damage to their hosts with no net benefit to themselves. Duplications in the germ line, on the other hand, would result in an increased number of progeny that carry the transposon in the next generation. Now, it is true, that this transposon (the P element) is horizonally transfered between species, but that has nothing to do with the point we were making. Your point about "no new functions except by horizontal transfer" is really overstating the case. In my own field of maize genetics it is quite clear that subtle changes in gene expression due to point mutations can cause changes in phenotype that are remarkably similar to changes that we know have occurred in maize domestication. Further, there are many examples of large gene families, all of which arrose from a single progenetor, that have taken on various new functions. Certainly this is a source of new variation that did not necessarily result from horizontal gene flow. Similarly, point mutations are only one kind of mutatagen at work. Transposons can be a rich source of sophisticated mutations, such as those that reprogram gene expression. Again, these transposons may be endogenous mutagen, not introduced from without (or above). Although I'm sympathetic with anyone arguing against the dominant paradigm, I think you are in danger of overgeneralizing and grasping to tightly to anything that makes panspermia more likely. In the end, I think it weakens you case.
Respectfully, Damon Lisch
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Date: Mon, 10 Sep 2001 19:46:19 -0500 ...From: Brig Klyce
Dear Damon --
Thank you for your recent feedback. I would have replied sooner, but I was away from the computer all weekend....
Your work shows, you say, that the P-element transposon is often "downregulated" in somatic cells but not in germline cells. And the P-element transposon can be horizontally transferred, we agree.
I wrote, "some transposable elements preferentially target the germline cells and avoid somatic cells when they invade."
If I had written, "some transposable elements preferentially become permanently installed in germline cells and not somatic cells," would you still see evidence that I am confused? And can't this occur after the transposons are acquired by horizontal transfer? I'm not sure what I am missing here.
As for "no new functions except by horizontal transfer," yes, I am suggesting that a fully scientific theory could include this principle. But I never said that you were promoting this idea. That would be "overstating the case." I assure you, no one at the conference got that impression from me. I simply said that your work adds credibility to the mechanism that I endorse, not that you endorse my mechanism.
You say, "subtle changes in gene expression due to point mutations can cause changes in phenotype that are remarkably similar to changes that we know have occurred in maize domestication." I agree that artificial and natural selection depend on the same genetics.
More generally, I find the evidence that the darwinian mechanism can account for sustained evolutionary progress (vs speciation, adaptation, or microevolution) to be very weak. Now that we know that the biosphere could receive input from outside, there is another way. I am advocating closed system experiments -- in biology or computer models -- to probe the issue.
I welcome your additional comments. I want to understand how evolution works!
Thank you. Brig Klyce
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Tue 1:32 PM
Dear Brig,
>Your work shows, you say, that the P-element transposon is often "downregulated" in somatic cells but not in germline cells. And the P-element transposon can be horizontally transferred, we agree. I wrote, "some transposable elements preferentially target the germline cells and avoid somatic cells when they invade."
The point is that the transposon doesn't target the germline during invasion, it is active in the germline to facilitate VERTICAL transmission (form parent to offspring). That is to say, the tissue-specific activity has nothing to do per se with horizontal transfer. Now, P elements do horizontally transfer, which wouldn't occur unless they got into the germline (the egg). However, that is a function of the vector for transfer possibly a parasitic mite), not any special regulatory mechanism of the P elements. The idea is that P elements are active only in tissues that facilitate transfer from parent to offspring, and not in somatic tissue, in which activity would cause harm to the host with no benefit to the transposon.
>If I had written, "some transposable elements preferentially become permanently installed in germline cells and not somatic cells," would you still see evidence that I am confused? And can't this occur after the transposons are acquired by horizontal transfer? I'm not sure what I am missing here.
Again, I'm afraid you are still confused. The P element is present in every cell of the fly. It is only active in some cells (the germ line), because it "wants" to transmit more copies of itself to the next generation.
>...I simply said that your work adds credibility to the mechanism that I endorse, not that you endorse my mechanism.
I should point out that this wasn't my work. I wrote about the work with Margaret Kidwell (who has done a great deal of work on P elements). We didn't "announce" this result; it had been in the literature for many years. Rather, we were using this as an example of instances in which transposons can modulate their "behavior" in such a way as to reduce thier impact on host fitness. At any rate, it's always best to cite primary literature (available freely at PUBMED on the internet).
>...I agree that artificial and natural selection depend on the same genetics.
Yes, but the point was that subtle changes in the time and position of gene expression can have profound effects on phenotypes. If, for instance, you mutate only three or four genes in maize you get something that looks remarkably like its progenetor species. Thus, you don't necessarily need horizontal transfer to explain significant morphological shifts during evolution. Now, bacteria are extra promiscous with respect to horizontal transfer, and I think transfer has been documented even between yeast and bacteria, so I think the case for a massive influence of horizontal bacterial evolution is a stronger one. However, not of that says that the genes came from anywhere but earth.
...As a geneticist who has worked on both classical genetics and molecular evolution, it is hard for me to see how anyone can call the evidence for darwinian evolution as the mechanism for evolutionary change "weak". When you compare genes and genomes between related species at the DNA sequence level, you really start to get a feel for how changes in DNA sequence are reflected in changes in morphology. I would really urge you to pick up a molecular evolution text book and read it with an open mind. I would reccomend Molecular Evolution by Wen-Hsiung Li. It gives an excellent overview of the state of the field.
...I hope I don't come off sounding to pissy. In my experience molecular evolution is a field with very big egos and much too much acromony. I wish you the best in your investigations!
Damon
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Tue 2:16 PM
Dear Damon --
Thanks for yours. Obviously we disagree about the mechanisms behind evolution, and there is an opportunity for the acrimony that you mention. Therefore I especially appreciate your civility.
We may have overworked the transposon issue, but I still think that your point supports my original point. You now say, "the transposon ...is active in the germline to facilitate VERTICAL transmission (form parent to offspring)." Later, "[the transposon] "wants" to transmit more copies of itself to the next generation." My original point was that contrary to previous opinion, some horizontally transferred elements (after transfer) are subsequently vertically inherited with striking efficiency. Do you disagree with this (last previous) sentence?
I was not aware that the transposon is present in all the somatic cells -- thank you for that clarification.
You say, "...P elements do horizontally transfer, which wouldn't occur unless they got into the germline (the egg)." I was under the impression that some horizontal transfer affects somatic cells only and does not have an inheritable effect. Is this wrong also? If it is, then why was there ever any argument against horizontal transfer as an evolutionary force in the first place?
Thank you also for recommending _Molecular Evolution_ by Wen-Hsiung Li. I have read most of it, and I especially studied Chapter 12, "Evolution by Transposition and Horizontal Transfer."
You wrote, "...it is hard for me to see how anyone can call the evidence for darwinian evolution as the mechanism for evolutionary change "weak"." I didn't. Where you have "evolutionary change," I wrote "sustained evolutionary progress." The difference is important. Too often it is ignored by Darwinists. On this issue I like an essay by a creationist, Lee Spetner. (I am not a creationist.) He avoids the terms macroevolution and microevolution, instead using "evolution A" and "evolution B."
http://www.trueorigin.org/spetner1.htm
I welcome your additional comments. I would like to learn from you. I apologize for my argumentative style....
Thank you. Best regards. Brig
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Date: Tue, 11 Sep 2001 13:53:50 -0800 ...From: Damon Lisch
>...My original point was that contrary to previous opinion, some horizontally transferred elements (after transfer) are subsequently vertically inherited with striking efficiency. Do you disagree with this (last previous) sentence?
The "striking efficiency" you mention comes from the capasity of transposons to duplicate themselves, thus making them overrepresented in progeny. I just want to be clear that, although your point that there is any horizontal transfer is a good one (and it certainly opens the door to the idea that other genes may be transfered as well), the tissue in which the element is active is not really germain. Enough said about that.
>...I was under the impression that some horizontal transfer affects somatic cells only and does not have an inheritable effect. Is this wrong also? If it is, then why was there ever any argument against horizontal transfer as an evolutionary force in the first place?
Well, viruses horizontally transfer all of the time, and that's no surprise, and yes, it was a big surprise that transposons (or any genetic material for that matter!) could transfer between species and then be vertically transfered. However, I've found in many evolutionary arguments (especially between geneticists and evolutionary biologist) that frequency matters. How often, what kind, etc... The argument against horizontal transfer was perfectly reasonable in the absence of evidence for it. Now almost no one doubts that it can occur. The only question is, how frequently, and to what extent has it influenced evolution? I would caution you that transposons are a special case, because they can spread very rapidly within populations and they can transpose between vector DNA (such as a virus) and host DNA.
...Speaking as a corn genetisist, I've seen would looks very much like "macroevolution", or evolution A, due to changes in a single gene in the absence of horizontal transfer. I could send you pictures of corn mutants that you wouldn't recognize as corn. Thus, the only question is, what kind of mutations may have contributed to macroevolution, and to sustained evolutionary "progress". Let me suggest that the way that kind of macroevolution can occur is through changes is the expression and timing of regulatory genes, rather than the introduction of new genes. To my mind, the really interesting question is how gradual that change is, and how many genes are involved. Traditionally the important mutations have been "black boxed" by evolutionists, mostly because we didn't know what they were. However, now we have a whole bunch of candidate genes and we are starting to look at exactly how they changed in different species, and how those changes are reflected in morphological evolution.
Look, we (none of us) know exactly how evolution works, and I personally think that the sheer randomness and seemingly arbitrary nature of Darwinian evolution offends something basic in our sense of order. It implies very directly that there is no God, no planner, no program, no progress. But that doesn't make it untrue. To tell you the truth, I think it has a Zen-like beauty to it. Evolution isn't a plan, it is a process. It just is. That, to me, is very cool, but it goes against everything we accept in our own lives. It is a profoundly revolutionary idea, and, like quantum mechanics, it is profoundly inaccessible on an emotional level. Still, it has a certain elegance!
Damon
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Date: Tue, 11 Sep 2001 16:32:39 -0500
Dear Damon --
Thanks for your last and your continuing civility.
You say, "I could send you pictures of corn mutants that you wouldn't recognize as corn."
I don't doubt that for a minute. But the critical piece for evolutionary progress is not change -- even drastic change -- per se, but the invention of useful new traits or features, like photosynthesis, oxygen metabolism, multicellularity, cell specialization, etc., etc. Few if any such inventions have been shown to be produced by the darwinian mechanism. None has, if you admit that strong panspermia is possible.
I am very interested in knowing about closed system experiments that examine biological evolution. I am aware of ones done by Richard Lenski at Michigan State (pretty sure it's there). If you know of others, or if you do them yourself, I would like to know about it.
Thanks!! Best regards. Brig
Panspermia Asks New Questions is the referenced CA webpage.
Viruses and Other Gene Transfer Mechanisms is a related CA webpage.
Subject: Panspermia / San Diego
Date: 8/22/01 11:06 AM
From: Brig Klyce
To: Sam Kounaves
Dear Sam --
I enjoyed meeting you in San Diego. I enjoyed your paper, and I enjoyed the lunch with you and Chandra Wickramasinghe. However, for all our walking, the food could have been better!
I realize that Chandra and I came on strong about the weakness we see in Darwinism. You were kind to entertain our views so equanimously.
There is one point I would like to clarify. I understand that there was a rumor in San Diego that I use panspermia as a front for my real, creationist views. I do not know the source of this rumor, but because you do not know me well and you listened to my arguments against Darwinism (as a mechanism for evolutionary progress), you may have believed it.
I am not a creationist. This misapprehension damages me, and it could be damaging to science, so I want to be very clear about it. The theory I am promoting, strong panspermia, has nothing to do with creationism. True, some of the arguments I make against Darwinism are similar to ones creationists make. But my alternative is completely different from theirs. Furthermore, I am a person of integrity. Whatever views I hold, I hold them openly.
The strong version of panspermia that I promote is strictly scientific, or materialistic, if that is clearer. Under this theory, at no time in the past is any miracle required. If you are interested in knowing more about the difference between strong panspermia and creationism, the following webpages, that have been posted for five years, two years, and one year, respectively, will be helpful, I hope:
http://www.panspermia.org/mechansm.htm
http://www.panspermia.org/proof5.htm
http://www.panspermia.org/astrobio01.htm
If you were never under any misapprehension about my views, I apologize for this possibly tiresome message. As you can tell, I am slightly bent out of shape over this.
Again, I enjoyed meeting you. I hope we will meet again soon. Thanks.
Best regards. Brig
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Samuel Kounaves - 8/23/01 2:59 AM
Dear Brig...
I also enjoyed meeting you in San Diego and hope to see you at future conferences. I must say that your hypotheses for panspermia and evolution catalyzed several debates among several of my colleagues. Thanks for your panspermia website references. I read them and they do put forth some provocative ideas.
I had several conversations with Chandra and hope to speak to him in the future also. It did appear that Chandra and you "came on strong" in your criticisms of Darwinism. However, I personally never considered your philosophy to be in the creationist camp even though some of your arguments did sound like creationist arguments. However I did notice on your website that you often reference creationists in support of some of your arguments. For example in your second link (proof5.htm) you reference "A Scientific Critique Of Evolution" by Spetner. I don’t remember where right now, but I’ve seen a couple of excellent rebuttals to his latest critique (I’ll try to dig them out for you if I get a chance). I emailed a copy of it to a biologist here at Tufts and she said that his arguments show a total lack of understanding of evolutionary biology. Even when I looked at them, I could see serious flaws.
I have over the years been impressed by how easily all the creationist arguments against evolution have been refuted by many of my colleagues in the evolutionary biology field. Evolution may have several areas of contention but I feel that the theory is basically an accurate description of the process as it occurs in nature.
As a I said to Chandra (and I think we also discussed) there are many in the scientific community who see no problem with the concept of microbial transfer between planetary bodies and perhaps even intragalactic. I presume this is the "weak form" of panspermia and I think there is enough evidence to support it.
I have a suggestion, which I also made to Chandra, that would allow panspermia to gain more support (and which I think is scientifically valid). In my opinion, I see NO reason for panspermia to be in conflict with natural selection or any parts of Neo-Darwinian theory. One could imagine the seeding of life via panspermia - the slow evolution of such life over several billion years - perhaps a second "seeding" about a billion years ago - and the continued evolution via natural selection.
Why can’t panspermia accept Darwinian evolution and ADD to it the a panspermic mechanism. This battle sounds similar to the punctuated equilibrium battles fought by Gould and Eldridge in the 70’s. The difference was that they incorporated their theory within the Darwinian frame work. Is there any reason why panspermia can not be overlaid on Darwinian theory (or visa-versa)???
Until such time that overwhelming evidence shows "strong" panspermia to be valid, would it not be better to have the support of a larger segment of the scientific community? Is anything gained by giving the "impression" that you are a creationist in disguise?
It seems to me you’ve got the worst of both worlds! You are attacked on the one side by creationists because you basically espouse a naturalistic theory and on the other side by scientists because you are attacking evolution. From my vantage point it seems there is no accord to be reached with the supernaturalists BUT I see no basic conflict in a synthesis of panspermia and Darwinism.
Anyway, sorry for this long rambling email.
Best regards, Sam
Prof. Samuel P. Kounaves / Department of Chemistry / Tufts University...
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8/23/01 6:05 PM
Dear Sam --
Thank you for your thoughtful reply. I appreciate your taking time to comment so carefully on strong panspermia and creationism.
I would like to respond to some of your points, in the hope that we may understand each other.
There are billions of Darwinists in the world and billions of creationists, and several dozen advocates of panspermia. I am basically desperate for allies, so when someone says something that I agree with, I endorse their message without imposing any litmus test on them.
I reference Spetner because I read his book and I read the essay that I link to, and I agreed with his objections to Darwinism almost 100%. While I do not endorse any alternative to Darwinism except strong panspermia, I accept any help in opposing what looks like a bad idea to me. You mentioned that your colleague saw problems and you see problems with Spetner. Do you mind elaborating on those problems?
I have witnessed several times the casual trashing of minority views, only to find that the trashing itself is completely shallow. For example, Robert Shapiro trashes Hoyle and Wickramasinghe's analysis of interstellar dust. I interviewed Robert Shapiro about it by email, and there was no substance to his trashing. See http://www.panspermia.org/replies2.htm#shapiro
For another example, I recently read a debate between William Dembski (creationist) and Tom Schneider (Darwinist.) Schneider says that Dembski's CSI is not different from Information as defined by Shannon. It has been a year or more since I read Dembski's last book, but Dembski's distinction between the two is very clear. Schneider's analysis is wrong.
Creationist arguments are often, but by no means always, bad. Darwinists behave as if they are always bad, so there's no need to understand them.
Thank you for your suggestion that panspermia and Darwinism can peacefully co-exist. I am aware of this possibility, and I would willingly go along if I believed it. But as I argued, perhaps too forcefully, I do not see the evidence for Darwinism *as the mechanism behind evolutionary progress*. I simply see strong panspermia as far more plausible. Seriously.
You wrote:
"Until such time that overwhelming evidence shows "strong" panspermia to be valid, would it not be better to have the support of a larger segment of the scientific community? Is anything gained by giving the "impression" that you are a creationist in disguise?"
Of course it would be good to have broad support. But I would lack integrity to proclaim views that I do not hold. As for giving the impression that I am a creationist in disguise, I go to some lengths to be clear about that in person and on my website. I appreciate the opportunity you have given me to elaborate my views to you.
Thank you again for your time. Please tell me where Spetner is wrong!!!
Thank you! ... Best regards. Brig Klyce / Acorn Enterprises LLC ...
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Samuel Kounaves / Fri 2:42 PM
Dear Brig...
I would like to respond in detail to your last email, but I'm overwhelmed with work this semester (teaching & research & family!). So it may be a while before I can get back to you with more details, but I definitely want to. I agree with you that many claims are hollow when examined closely. I have always tried to insure that my statements could be substantiated with sufficient evidence and references.
I have over the past 20 years gotten into some protracted debates with several creationists. In all that time they have never provided to me any evidence that on closer examination held up. (I guess we might be destined to disagree here, since I would say 99% of creationist claims are hollow and only 10% of evolutionist's are.) I am not an expert in many of the areas in contention, but I have always sought the advice of my trusted colleagues who are. This is one reason I suggested that you are "scientifically" on sounder ground synthesizing panspermia with Darwinian evolution than appearing to ally with creationists.
Four points that I will try to address further, in addition to the rebuttal to Spetner, are :
1. I am quite convinced that the Darwinian model is a reasonably accurate representation of the evolutionary process as it has occurred and occurs in nature. However, I still see no problem with the "weak" form of panspermia causing a perturbation in the process (i.e., one of the many forces directing natural selection). When and how much are the sticking points.
2. Scientifically, I currently see strong panspermia as a "speculation" as opposed to an "hypothesis" or a "theory". In some ways your position is analogous to that of the "theistic evolutionists" who accept micro-evolution but insist that God intervened(s) at specific points for the "macro" portion. I have still to see any sound evidence for either and have been convinced by my biologist colleagues that evolutionary biology and genetics can account for both macro/micro rather well.
3. I also have been convinced by several evolutionary and molecular biologists that new genetic programs (increased information) are indeed "well-accounted for by known genetic mechanisms".
4. The strong form of panspermia requires that new genetic programs "arrive" on Earth and have always existed. Thus, this part of panspermia requires abandoning the big-bang model. The evidence for the BB is more than speculation, and many cosmologists would say more than an hypothesis. Thirty years ago I was convinced of a "steady-state" universe. It appealed/s more to me than the BB concept. But, over the past decades the evidence does not seem to support this hypothesis. I have read several items by people such as Burbidge, Hoyle and Narlikar in opposition to the BB, but they have not been convincing enough and do not, in my opinion, refute the BB. (for philosophical reasons, I think many of us would love to see the steady-state model come back.. but alas!)
To provide you with reasonable and documented responses to these and my previous statements will require some effort on my part. I am willing to try and do this, but it will take some time.
Fred Hoyle has made several outstanding contributions to science, whether panspermia will turn out to also be one will have to await stronger and clearly unambiguous evidence (a least to convince me and much of the scientific community).
Regards ...Sam
Prof. Samuel P. Kounaves / Department of Chemistry / Tufts University...
Prof. Kounaves' followup will be posted here when it is received.
Evolution vs Creationism is a related CA webpage.
Subject: Terms & Conditions
Date: 15 August 2001
From: Ken Jopp
Hello Brig, I hope your summer is going well. I just wanted to chime in with a couple comments about the growing acceptance of "Pseudo-panspermia" Mainly, you might want to reconsider the term. What's gaining acceptance it seems is not so much a false panspermia, but a Quasi-panspermia. In other words, it's not a sham or deception, but rather a similarity, in the form of a weak version of the original.
[Klyce, 16 August, italicized] Agreed, it's not false, but it's too weak.
In fact, "weak" and "strong" are standard terms that attach themselves to scientific theories. The Anthropic Principle, for example, is often characterized as having weak and strong forms. Hoyle advocates Strong Panspermia. The variant gaining acceptance is Weak Panspermia.
Weak panspermia is the original panspermia -- life on planets gets seeded by whole cells from space. Strong panspermia involves evolutionary progress after the first cells get established. I have been promoting this convention for several years now.
Also, The growing recognition of comets as the "delivery system" would seem to beg the question, why Earth only?
For the same reason that there are no palm trees in Antarctica. Wrong climate, nutrients, daylight, temperature or something.
Why haven't Mars and Venus been terraformed by their own cometarily delivered life? Why no Martian or Venusian Gaia?
Don't be too sure there hasn't been.
Does Earth alone occupy some viability zone in terms of distance from the Sun?
Possibly. Perhaps there's a combo of distance, planet size, etc.
But it would seem that extremophiles would be able to get a foothold on the other planets. If there once was unicellular life on Mars, why did it fail to thrive and evolve?
The problem today is that there's not enough water on Mars for life to thrive. Dunno exactly how this came about. Weaker surface gravity may have contributed. There may be enough water for single-celled life to survive on Mars.
To your knowledge, has anyone tried to define the unique conditions of the Earth that made it hospitable in a way that the nearby planets were not?
Yes, more than one person. Recently, the book Rare Earth by Ward and Brownlee tackles the question.
(If I remember right, you're in North Carolina. I was there last week,vacationing on Oak Island. It's our fourth trip to the Outer Banks (I think Oak is considered part of the Banks), and it was a wonderful experience, though I could have done without the beach "renourishment" project.)
Best regards, Ken
Glad it was fun. I'm in Memphis. At one time in history, Tennessee was part of N.C., but no longer! Thanks for the comments.[...] Brig
20 August 2001, from Ken Jopp:
Dear Brig [...] As for the "weak" and "strong" terminology, I suppose one could define a multi-tiered heirarchy from weakest to strongest:
- Precursor molecules from space.
- Whole, viable cells from space
- 2 plus ongoing evolution and/or diseases from continuous infall
- 3 plus Gaian feedback mechanisms (I think this is your intended meaning with the term "Cosmic Ancestry")
- 4 plus sociobiology, Chomsky's "universal grammar", Jungian "archetypal" psychology (such a radical extension of the theory rests on Hoyle's explanation of evolution from space in terms of standardized genetic "subroutines" that get spliced together in various ways to produce the diversity of species. If the generalized patterns that one finds in social behaviors, language, and psychology have genetic roots, then they too might best be understood as governed by a set of standard subroutines that are capable of combining in various, but limited, ways.)
- 5 plus ???
As for the "Rare Earth", that idea seems to be at odds with the general tenor of Panspermia, aka, "seeds everywhere". The "rare Earth" idea argues for the unlikeliness of other life-bearing planets anywhere, because Earth's hospitability (is that a word?) to life depends on so many coincidences. It will be interesting to watch the developments as astronomers detect planets around other stars, if they are able to discern whether or not a "rare" (life-bearing) planet is a standard fixture of a solar system, or whether we really are alone -- or a least "rare".
Ken
Kevin Keogh comments, 16 Aug 2002.
Subject: My congratulations
Date: Sun, 10 Jun 2001 16:04:01 -0500
From: Danilo José Antón Giudice
Dear Dr Klyce:
I've reading your site with much interest. You are providing highly valuable information on a very important subject. My name is Danilo Anton (60 years old), I am a geographer and a writer (12 books) mainly dealing with multidisciplinary issues (environment, water, anthropology, etc).
I am from Uruguay and I've worked in many countries, such as Canadá (I worked for IDRC of Canada for 13 years), taught in the United States, Mexico, Saudi Arabia, France, among others. Presently, I am doing research on water issues at the University of the State of Mexico in Toluca.
I am really impressed with your Cosmic Ancestry Theory and would like to help in any way that may be possible to disseminate these ideas. One thing I could do is to translate some of your articles in Spanish (I have translated into Spanish several books and articles already). These translations could be used by you in your site, if you wish, or given to other sites willing to spread the Cosmic Ancestry- Panspermia Theories. I do not want to obtain any profit from this work.
Just for your information, my last book in English, published in Canada by IDRC Books, is called Diversity, Globalization and the Ways of Nature (Anton, D., 1995) which you can find at www.idrc.ca/booktique I've just finished another book (in Spanish) titled: "Peoples, Drugs and Serpents" (Pueblos, Drogas y Serpientes) which deals with the origin of life (my own view of panspermia, not so different from Cosmic Ancestry), evolution of human consciousness, the mysterious role of DNA, the relationship between humans and plants and the contemporary need of a new paradigm to address society problems (including the unnecessary witch hunt which the media, call "drugs war"). It will soon be published in Costa Rica.
Again, my congratulations for your site, and keep the good work.
Sincerely yours
Dr. Danilo Anton / danton@chasque.apc.org / ciramex@coatepec.uaemex.mx
Subject: Eukaryotes to prokaryotes in 15 days
Date: 9:17 AM, Fri, 1 June 2001
From: Brig Klyce
To: Douglas Robinson
Dear Dr. Robinson --
I have read with interest your report on the evolution of prokaryotes from altered human cells in 15 days. My organization is interested in panspermia and its possible implications for the mechanisms behind evolution. Your experiment is so remarkable that it would influence our thinking dramatically, if it stands up. But to influence mainstream science, a result as remarkable as yours needs confirmation and peer acceptance, I would think. So I am curious, has your experiment been published in any journals, or reviewed in them? How has your experiment been received by the scientific establishment? Has anyone not affiliated with you endorsed your report?
Any response will be welcome. Thank you. [...]
From: Douglas Robinson
Date: Thu, 21 Jun 2001 23:11:11 -0400
Dear Brig,
I appreciate your review of the research article "An Oxygen-Related Bioprocess Drives Eukaryote-to-Prokaryote Genome Evolution and Speciation." I believe you have summarized the major points of the work well.
The experiments described have been published only online on the Internet, the modern-day Guttenberg press. The work has been reviewed favorably by several biological scientists including a Nobel laureate, a member of the Genome Analysis Group of the International Human Genome Sequencing Consortium and a biochemist who is at the forefront of evolutionary biology thinking. Some reviewers suggested that the research article be submitted to one of the top-tier science journals. I declined to do so for several reasons including the length of the article and its novelty which appears to transcend the current aims and scopes of these journals.
An earlier version of the research article was submitted to a journal of molecular evolution. After initial interest and a prolonged back-and-forth communication with the editors, the work was rejected finally by one editor who wrote "In particular, no matter how carefully controls are carried out, the alternative explanation that indeed there was contamination is in my mind much more likely than spontaneous production of a prokaryotic cell." (italics mine) So much for empirical science! The implication by this editor that I am proposing a type of 'spontaneous generation' was a little surprising. This highlights further the gap in understanding that exists between the evolutionary worldview this work presents and that held by many molecular evolutionists. Post publication online, I communicated the article to the editors of three top-tier journals.
It is not surprising that the work has met with skepticism, considering its novelty. According to Kuhn (1), scientists do not "… normally aim to invent new theories, and they are often intolerant of those invented by others." On the other hand, the explanatory power of a scientific theory correlates positively with its degree of improbability (2). It follows that the more improbable a theory is (and, hence, its initial rejection by many scientists), the greater its chances of uncovering a 'new' secret of Nature if corroborated.
I am content that despite considerable resistance from some quarters, peer acceptance and endorsement by others has led to collaborations to study the bioprocess and develop applications in both the United States and overseas. As for corroboration of this evolutionary bioprocess, please review the independent 'validation study' published online at http://www.denovo-bio.com/bioprocess4.htm. This fastidiously controlled study, conducted by a biotechnology company well-known for its sterility testing of cell lines and biologicals, confirms the findings by my laboratory.
Finally, I wish to clarify some points related to the experimental findings. With nucleotide databases current to December 2000, approximately 60% of shotgun library DNA sequence sampling from the representative prokaryote W genome were found to match no sequences contained in these databases according to sequence alignment methods stipulated (NCBI GenBank nucleotide databases and BLAST programs). As testament to the rapid expansion of nucleotide databases and the improvement of sequence alignment programs (the latest in silico analysis of April 2001 uses the EMBL nucleotide databases and the WU-BLAST2 program), many of these 'no-match' sequences subsequently were found to have significant similarities to phylogenetically diverse nucleotide sequences. These DNA sequence similarities include those to human-like DNA sequences, plant-like DNA sequences, fungus-like DNA sequences, unicellular eukaryote-like (paramecium) DNA sequences and chimerical DNA sequences, i.e. bacterium-like/human-like DNA sequences.
These recent data support the conclusion that the eukaryote-to-prokaryote genome evolution and speciation involves widespread recombination and a process of 'vertical' DNA transfer. The magnitude of DNA recombination, as indicated by the phenotypic diversity of these DNA sequences, and the amount of phylogenetically diverse (and non-bacterium-like) DNA sequences transferred from eukaryote to prokaryote are incompatible with what is currently known about 'lateral gene transfer.' I refer you to the research article postscript for an in-depth reporting and discussion of these findings.
I invite other scientists to confirm further these findings on the principle that "seeing is believing." I would be very happy to assist other laboratories regarding the relatively simple technical aspects of the bioprocess.
Again, Brig, thanks for your review. As to how this work potentially relates to the theory of panspermia, have you considered the possibility that a space-traveling eukaryotic life form seeded life on Earth?
Best regards, D. Robinson
1. Kuhn, T.S. The structure of scientific revolutions (The University of Chicago Press, Chicago & London 1962, 3rd edition 1996)
2. Popper, K. R. Conjectures and refutations (Routledge, London & New York 1963, 5th edition 1989)
May 28: Eukaryote-to-prokaryote evolution in 15 days?! is the related CA What'sNEW item.
Subject: Consciousness?
Date: Fri, 18 May 2001 23:11:34 +0100
From: raywhit@appleonline.net
Dear Brig,
First, may I offer my utmost thanks and appreciation for your Web site 'Cosmic Ancestry', which , in my humble opinion, fills a gap in the generally available discussion on Evolution, Creation, etc.
Second, I think it is only fitting that I give a 'resume' of 'Where I'm coming from' !! after all there is great polarisation in these topics, and it's only natural that opinions stated will be 'coloured' by their source! By profession I'm an Electronics Engineer and was born (1942 ) / reside in the UK. My 'generic' religion is C of E, that is as far as the State is concerned! ( i.e.:- official organisations have to register you as something! ) , however I do not consider myself bound by ANY religious dogma - reckon that makes me Agnostic, or something? My wife is an RC, and does attend Church occasionally, the Kids are, well Students (Jedi) ?!? All my life I've had a 'passion' for Science & Technology, as well as the historical context for the many great advances we see today -- and sometimes yesterday! My job in electronics demands a deep understanding of both hardware and software principles, and it is in relating this type of discipline to the current paradigms of 'why the hell are we here?' that I find the explanations offered just do not 'hack'
OK, so now I'll start!
Firstly, Creationism. This solves everything in a simple and final manner, life exists because of the Creator. Any modifications made by 'US' are directly linked to Him, as we were Created in His image, Period. Simple, economic, universal, no need for multibillion $ atom smashers to get a proof, just go to your local Church, Temple, or whatever! This one must be the Accountants dream!!! I'm not knocking Religion, it's on the ball as far as it goes, BUT it stops short of a 'scientific' solution.
Secondly, Darwinism ( & the neo type! ). This seems to have attained almost a cult status, its proponents claim it solves everything, let an obstacle arise and its neatly bypassed. Moreover it appears to have a crucial function in modern scientific thought. Recently I heard in a BBC documentary program (Horizon? ) that if Darwinism were to fall then science would regress 150 years - obviously this could not be allowed to happen at any cost! In consequence many palaeontology discoveries are being immediately touted as proof of this Victorian scientist's theory - and as on the BBC documentary quoted; exit to images of a baby in the womb? OK, what's wrong with the evolution theory? statistics and logic for a start, followed by its very restricted frame of reference, more on this later.
Thirdly, panspermia. I'm not sure where this falls in reference the first two items? I suspect it could give a 'cop out' to both. I like the idea, and it seems that in a few years we may get irrefutable evidence one way or the other from space exploration, perhaps the truth is already known? What is for sure is that the Evolutionists and Creationists will integrate the data into their respective dogmas. It is an especial plus for the Evos' as it gives them more time to counter those 'dam' statisticians, and the Creas' will only marvel on the all inclusive hand of God.
An Engineers view.
Surely we are taking a very narrow view on this important subject, I mean that at present, as in many fields of Human endeavour, the so called experts are drawn from a very small section of the scientific spectrum. For instance genes and genetic code are the 'Holy' province of the microbiologist, and higher organisms the province of anthropology etc. Surely all these things are linked, and the only real approach should be the holistic one which encompasses the full spectrum of knowledge.
The holistic approach leads us to very interesting area for the definition of life. Let us take what is at present considered to be an Object, say a PC or Automobile, does it have life? was it Created or did it Evolve? Well I suppose one can answer yes to both, but we all know this isn't life. Why isn't it, dad? Its a material artefact made by intelligent Humans OK? If we persist in this 'childish' questioning I could ask 'what is material?' Is a Tree material? No its vegetable. Well what's the difference between a Tree and a PC? They serve different purposes. Who made them? God made the tree (or Charles Darwin), and Apple made the PC, But Apples grow on trees. OH SHUT UP!!!
This problem stems from our strict compartmentalisation of the various disciplines, and even worse the sub-compartmentalisation within disciplines. In what has become known as science we have Physics (divided into Astro, Particle, &...) , Chemistry (divided into organic & inorganic &...), Biology (divided in, oh so many bits) . Then we have Math (which covers everything), Theology, Philosophy, etc. etc. etc. The trouble is that most of these disciplines do not communicate with each other, and indeed can object violently if such contact is suggested, (keep of my patch syndrome! )
In a holistic approach all matter is equivalent. Going from the lowest point we could start from the ZPE of the vacuum and work up through the sub atomic particles to atoms to combinations of atoms (Chemicals) to combinations of chemicals (molecules) to great accumulations of this 'matter' to form Nebulae, Stars, Planets, and ultimately the Universe. All of this relates to the elemental energy of the vacuum, or as religion states Dust to Dust, Ashes to Ashes. A common practice in engineering is to 'reverse engineer' an article in order to copy or improve it. Lets reverse engineer an Automobile, we strip it down to component level, we investigate manufacturing methods, we investigate the design objectives, we consider what its used for: